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SNS-032

A potent CDK (cyclin-dependent kinase) inhibitor
Catalog #: 9490
SKU-Size Size Price Qty
9490-5 5 mg
$145.00
9490-25 25 mg
$575.00
More Sizes Get Quote

Product Details

Alternate Name N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide; BMS-387032
Appearance White solid
CAS # 345627-80-7
Molecular Formula C₁₇H₂₄N₄O₂S₂
Molecular Weight 380.53
Purity ≥98% by HPLC
Solubility DMSO (>15 mg/ml)
SMILES CC(C)(C)C1=CN=C(O1)CSC2=CN=C(S2)NC(=O)C3CCNCC3
InChi InChI=1S/C17H24N4O2S2/c1-17(2,3)12-8-19-13(23-12)10-24-14-9-20-16(25-14)21-15(22)11-4-6-18-7-5-11/h8-9,11,18H,4-7,10H2,1-3H3,(H,20,21,22)
InChi Key OUSFTKFNBAZUKL-UHFFFAOYSA-N
PubChem CID 3025986
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

SNS-032 is a potent CDK inhibitor. Inhibits cyclin-dependent kinases (cdks) 9, 2 and 7 with IC₅₀ values of 4, 38 and 62 nM respectively. Displays no activity against 190 additional kinases (IC₅₀ >1000 nM). Prevents tumor cell-induced VEGF secretion and in vitro angiogenesis.


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