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Smo Antagonist, SA9

A Hedgehog (Hh) signaling pathway antagonist
Catalog #: 2155

In stock

SKU-Size Size Price Qty
2155-2 2 mg
$80.00
2155-5 5 mg
$180.00
More Sizes Get Quote

Product Details

Alternate Name 3-(3-(4-Fluorophenyl)-5-oxo-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinazolin-1-yl-N-(3-methylphenethyl)propanamide
Appearance Crystalline solid
Molecular Formula C₂₇H₂₈ClN₅O₂
Molecular Weight 490
Purity ≥95% by NMR
Solubility DMSO
SMILES C1CCC(=CC1)CCNC(=O)CCC2=NN=C3N2C4=CC=CC=C4C(=O)N3CC5=CC=C(C=C5)Cl
InChi InChI=1S/C27H28ClN5O2/c28-21-12-10-20(11-13-21)18-32-26(35)22-8-4-5-9-23(22)33-24(30-31-27(32)33)14-15-25(34)29-17-16-19-6-2-1-3-7-19/h4-6,8-13H,1-3,7,14-18H2,(H,29,34)
InChi Key YTDIPVZSLXYGNL-UHFFFAOYSA-N
PubChem CID 20880974
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

SA9 inhibits Hh pathway by interacting directly with Smo. It inhibits SAG (Smoothened agonist) activation of Hh signaling in Shh-LIGHT 2 cells (IC₅₀ = 19 µM). Induces the localization of Smo to cilia in ASZ1 cells, but not in IMCD3 cells. Also treatment of Ptch1-/- MEFs with SA9 suppresses the β-galactosidase activity (IC₅₀ = 1.0 µM) and inhibits the expression of Gli1 and Ptch1 in ASZ1 cells.


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