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Smo Antagonist, SA10

A Hedgehog (Hh) signaling pathway antagonist
Catalog #: 2159
SKU-Size Size Price Qty
2159-2 2 mg
2159-5 5 mg
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Product Details

Alternate Name 4-((Benzo[c][1,2,5]thiadiazole-4-sulfonamido)methyl-N-(3-phenylpropyl)cyclohexanecarboxamide
Appearance Crystalline solid
Molecular Formula C₂₃H₂₈N₄O₃S₂
Molecular Weight 472.62
Purity ≥95% by NMR
Solubility DMSO
PubChem CID
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


SA10 inhibits SAG (Smoothened agonist) activation of Hh signaling in Shh-LIGHT 2 cells (IC₅₀ = 5 µM). However, unlike SA1 and SA9, Smo antagonist SA10 does not directly bind to Smo. Inhibits the localization o Smo to cilia. Also treatment of Ptch1-/- MEFs with SA10 suppresses the β-galactosidase activity (IC₅₀ = 11.0 µM) and inhibits the expression of Gli1 and Ptch1 in ASZ1 cells.

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