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Smo Antagonist, SA1

A Smoothened (Smo) antagonist
Catalog #: 2154
SKU-Size Size Price Qty
2154-2 2 mg
$80.00
2154-5 5 mg
$180.00
More Sizes Get Quote

Product Details

Alternate Name 3-(3-(4-Fluorophenyl)-2,5,7-trimethylpyrazolo[1,5a]pyrimidin-6-yl)-N-(4-(furan-2-yl)butan-2-yl)propanamide
Appearance Crystalline solid
Molecular Formula C₂₆H₂₉FN₄O₂
Molecular Weight 448.53
Purity ≥95% by NMR
Solubility DMSO
SMILES CC1=C(C(=NC2=C(C(=NN12)C)C3=CC=C(C=C3)F)C)CCC(=O)NC(C)CCC4=CC=CO4
InChi InChI=1S/C26H29FN4O2/c1-16(7-12-22-6-5-15-33-22)28-24(32)14-13-23-17(2)29-26-25(18(3)30-31(26)19(23)4)20-8-10-21(27)11-9-20/h5-6,8-11,15-16H,7,12-14H2,1-4H3,(H,28,32)
InChi Key UTURPAUEBUIDJO-UHFFFAOYSA-N
PubChem CID 5308963
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A Smoothened (Smo) antagonist. SA1 inhibits Hh pathway by interacting directly with Smo. Inhibits SAG (Smoothened agonist) activation of Hh signaling in Shh-LIGHT 2 cells (IC₅₀ = 3.1 µM). Also inhibits the localization of Smo to cilia. Treatment of Ptch1-/- MEFs with SA1 suppresses the β-galactosidase activity (IC₅₀ = 3.8 µM) and inhibits the expression of Gli1 and Ptch1 in ASZ1 cells.


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