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Smo agonist, SAG dihydrochloride

A cell-permeable Smoothened (Smo) agonist
Catalog #: 2801
SKU-Size Size Price Qty
2801-1 1 mg
$185.00
2801-5 5 mg
$645.00
More Sizes Get Quote

Product Details

Alternate Name N-Methyl-N′-(3-pyridinylbenzyl)-N′-(3-chlorobenzo[b]thiophene-2-carbonyl)-1,4-diaminocyclohexane, dihydrochloride
Appearance Light yellow solid
CAS # 364590-63-6
Molecular Formula C₂₈H₂₈ClN₃OS. 2HCl
Molecular Weight 562.98
Purity ≥98% by HPLC
Solubility H2O (~ 25 mg/ml) DMSO (~ 10 mg/ml)
SMILES CNC1CCC(CC1)N(CC2=CC=CC(=C2)C3=CC=NC=C3)C(=O)C4=C(C5=CC=CC=C5S4)Cl.O.Cl.Cl
InChi InChI=1S/C28H28ClN3OS.2ClH.H2O/c1-30-22-9-11-23(12-10-22)32(28(33)27-26(29)24-7-2-3-8-25(24)34-27)18-19-5-4-6-21(17-19)20-13-15-31-16-14-20;;;/h2-8,13-17,22-23,30H,9-12,18H2,1H3;2*1H;1H2
InChi Key IYXUQUYRWPGIQL-UHFFFAOYSA-N
PubChem CID 71433770
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

SAG hydrochloride is the water-soluble analog of SAG (Cat. No.1939). A cell-permeable Smoothened (Smo) agonist that has shown to induce Hedgehog pathway activation and counteract cyclopamine inhibition of Smo. SAG has been reported to act as an activator at low concentrations, but can inhibit Smo at very high concentrations.


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