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A pim kinase inhibitor
Catalog #: 2211

Product Details

Cat # +Size 2211-5
Size 5 mg
Alternate Name 5E/Z)-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione
Appearance White to off-white solid
CAS # 327033-36-3
Molecular Formula C₁₁H₆F₃NO₂S
Molecular Weight 273.23
Purity ≥98% by HPLC
Solubility DMSO (>10 mg/ml)
InChi InChI=1S/C11H6F3NO2S/c12-11(13,14)7-3-1-2-6(4-7)5-8-9(16)15-10(17)18-8/h1-5H,(H,15,16,17)/b8-5-
PubChem CID 1361334
MDL Number MFCD01152003
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


A selective, ATP-competitive inhibitor Pim-1 (IC₅₀ = 21 nM) and Pim-2 (IC₅₀ = 100 nM) protein kinases. Blocks mTORC1 activity via activation of AMPK. SMI-4a has been found to inhibit prostate cancer cell growth and induce G1 phase cell-cycle arrest in precursor T-cell lymphoblastic leukemia/lymphoma cell lines.

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