Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]

SMI-4a

A pim kinase inhibitor
Catalog #: 2211
$130.00

Product Details

Cat # +Size 2211-5
Size 5 mg
Alternate Name 5E/Z)-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione
Appearance White to off-white solid
CAS # 327033-36-3
Molecular Formula C₁₁H₆F₃NO₂S
Molecular Weight 273.23
Purity ≥98% by HPLC
Solubility DMSO (>10 mg/ml)
SMILES C1=CC(=CC(=C1)C(F)(F)F)C=C2C(=O)NC(=O)S2
InChi InChI=1S/C11H6F3NO2S/c12-11(13,14)7-3-1-2-6(4-7)5-8-9(16)15-10(17)18-8/h1-5H,(H,15,16,17)/b8-5-
InChi Key NGJLOFCOEOHFKQ-YVMONPNESA-N
PubChem CID 1361334
MDL Number MFCD01152003
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A selective, ATP-competitive inhibitor Pim-1 (IC₅₀ = 21 nM) and Pim-2 (IC₅₀ = 100 nM) protein kinases. Blocks mTORC1 activity via activation of AMPK. SMI-4a has been found to inhibit prostate cancer cell growth and induce G1 phase cell-cycle arrest in precursor T-cell lymphoblastic leukemia/lymphoma cell lines.


Why buy BioVision Products?
Innovation
Affordability
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.