Product Details
| abID | ab142127 |
|---|---|
| Alternate Name | Small-Molecule Enhancer of Rapamycin-28;6-Bromo-4-allylaminoquinazoline |
| Appearance | Off-white solid |
| CAS # | 307538-42-7 |
| Molecular Formula | C₁₁H₁₀BrN₃ |
| Molecular Weight | 264.12 |
| Purity | ≥98% by TLC |
| Solubility | DMSO (~8 mg/ml) or EtOH (~ 2 mg/ml) |
| SMILES | C=CCNC1=NC=NC2=C1C=C(C=C2)Br |
| InChi | InChI=1S/C11H10BrN3/c1-2-5-13-11-9-6-8(12)3-4-10(9)14-7-15-11/h2-4,6-7H,1,5H2,(H,13,14,15) |
| InChi Key | BCPOLXUSCUFDGE-UHFFFAOYSA-N |
| PubChem CID | 1560402 |
| MDL Number | MFCD02166825 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Cell permeable. Acts as a positive regulator of autophagy, acting via mTOR-independent mechanism. SMER28 increases autophagosome synthesis and enhances the clearance of model autophagy substrates such as A53T a-synuclein and mutant huntingtin fragments. It is also protective in Drosophila model of Huntington’s Disease (HD).
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