A positive regulator of autophagy
Catalog #: 1856 | abID: ab142127

Product Details

abID ab142127
Alternate Name Small-Molecule Enhancer of Rapamycin-28;6-Bromo-4-allylaminoquinazoline
Appearance Off-white solid
CAS # 307538-42-7
Molecular Formula C₁₁H₁₀BrN₃
Molecular Weight 264.12
Purity ≥98% by TLC
Solubility DMSO (~8 mg/ml) or EtOH (~ 2 mg/ml)
InChi InChI=1S/C11H10BrN3/c1-2-5-13-11-9-6-8(12)3-4-10(9)14-7-15-11/h2-4,6-7H,1,5H2,(H,13,14,15)
PubChem CID 1560402
MDL Number MFCD02166825
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Cell permeable. Acts as a positive regulator of autophagy, acting via mTOR-independent mechanism. SMER28 increases autophagosome synthesis and enhances the clearance of model autophagy substrates such as A53T a-synuclein and mutant huntingtin fragments. It is also protective in Drosophila model of Huntington’s Disease (HD).

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