E3 Ubiquitin Ligase Inhibitor
Catalog #: 2514 | abID:

Product Details

Alternate Name 9H-Indeno[1,2-e][1,2,5]oxadiazolo[3,4-b]pyrazin-9-one
Appearance Yellow solid
CAS # 67200-34-4
Molecular Formula C₁₁H₄N₄O₂
Molecular Weight 224.18
Purity ≥98% by HPLC
Solubility DMSO (>30 mg/ml)
InChi InChI=1S/C11H4N4O2/c16-9-6-4-2-1-3-5(6)7-8(9)13-11-10(12-7)14-17-15-11/h1-4H
PubChem CID 568763
MDL Number MFCD00451458
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


SMER-3 (Small molecule enhancer of rapamycin -3) is a selective inhibitor of a yeast SCF family E3 ubiquitin ligase (SCFMet30) in vitro and in vivo. Induces the expression of MET genes that results in cell cycle arrest and blockage of cell proliferation.

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