Product Details
| Alternate Name | 9H-Indeno[1,2-e][1,2,5]oxadiazolo[3,4-b]pyrazin-9-one |
|---|---|
| Appearance | Yellow solid |
| CAS # | 67200-34-4 |
| Molecular Formula | C₁₁H₄N₄O₂ |
| Molecular Weight | 224.18 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (>30 mg/ml) |
| SMILES | C1=CC=C2C(=C1)C3=NC4=NON=C4N=C3C2=O |
| InChi | InChI=1S/C11H4N4O2/c16-9-6-4-2-1-3-5(6)7-8(9)13-11-10(12-7)14-17-15-11/h1-4H |
| InChi Key | SFSSAKVWCKFRHE-UHFFFAOYSA-N |
| PubChem CID | 568763 |
| MDL Number | MFCD00451458 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
SMER-3 (Small molecule enhancer of rapamycin -3) is a selective inhibitor of a yeast SCF family E3 ubiquitin ligase (SCFMet30) in vitro and in vivo. Induces the expression of MET genes that results in cell cycle arrest and blockage of cell proliferation.
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