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Smad3 Inhibitor, SIS3

A Smad3 inhibitor
Catalog #: 2227

In stock

SKU-Size Size Price Qty
2227-1 1 mg
$105.00
2227-5 5 mg
$385.00
More Sizes Get Quote

Product Details

Alternate Name (2E)-1-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-propenone hydrochloride
Appearance Yellow solid
CAS # 521984-48-5
Molecular Formula C₂₈H₂₇N₃O₃ ∙ HCl
Molecular Weight 489.99
Purity ≥98% by HPLC
Solubility DMSO (>20 mg/ml)
SMILES CN1C(=C(C2=C1N=CC=C2)C=CC(=O)N3CCC4=CC(=C(C=C4C3)OC)OC)C5=CC=CC=C5.Cl
InChi InChI=1S/C28H27N3O3.ClH/c1-30-27(19-8-5-4-6-9-19)22(23-10-7-14-29-28(23)30)11-12-26(32)31-15-13-20-16-24(33-2)25(34-3)17-21(20)18-31;/h4-12,14,16-17H,13,15,18H2,1-3H3;1H/b12-11+;
InChi Key CDKIEBFIMCSCBB-CALJPSDSSA-N
PubChem CID 16079005
MDL Number MFCD09265258
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A potent and selective inhibitor of Smad3 function. SIS3 selectively inhibits TGF-β1/ALK5-induced Smad3 phosphorylation. Also inhibits the TGF-β1 effect on type I procollagen expression at the transcriptional levels via the Smad3-binding site.


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