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A ROCK-II inhibitor
Catalog #: B3399
SKU-Size Size Price Qty
B3399-5 5 mg
B3399-25 25 mg
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Product Details

Alternate Name 2-[3-[4-(1H-indazol-5-ylamino)-2-quinazolinyl]phenoxy]-N-(1-methylethyl)-acetamide KD-025 SLx2119 KD025
Appearance Solid
CAS # 911417-87-3
Molecular Formula C₂₆H₂₄N₆O₂
Molecular Weight 452.5
Purity ≥98%
Solubility 25 mg/ml DMSO
InChi InChI=1S/C26H24N6O2/c1-16(2)28-24(33)15-34-20-7-5-6-17(13-20)25-30-23-9-4-3-8-21(23)26(31-25)29-19-10-11-22-18(12-19)14-27-32-22/h3-14,16H,15H2,1-2H3,(H,27,32)(H,28,33)(H,29,30,31)
PubChem CID 11950170
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


SLx-2119 is a potent inhibitor of ROCK2 that displays >200-fold selectivity over ROCK1 (IC50s = 105 nM and 24 µM, respectively). Rho-associated protein kinase 2 (ROCK2) regulates the formation of actin stress fibers and focal adhesions, smooth muscle contraction, and gene expression.

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