SKPin C1

An ubiquitin E3 ligase inhibitor
Catalog #: 2343 | abID:

Product Details

Alternate Name 2-[4-Bromo-2-[[4-oxo-3-(3-pyridinyl­methyl)-2-thioxo-5-thiazolidinylidene]methyl]pheno­xy]acetic acid
Appearance Yellow solid
CAS # 432001-69-9
Molecular Formula C₁₈H₁₃BrN₂O₄S₂
Molecular Weight 465.34
Purity ≥98% by TLC
Solubility DMSO (15 mg/ml)
InChi InChI=1S/C18H13BrN2O4S2/c19-13-3-4-14(25-10-16(22)23)12(6-13)7-15-17(24)21(18(26)27-15)9-11-2-1-5-20-8-11/h1-8H,9-10H2,(H,22,23)/b15-7-
Handling Protect from air and light
Storage Conditions -20 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Inhibits the cullin-RING ubiquitin E3 ligase SCF-Skp2. Selectively inhibits Skp2-mediated p27 degradation by reducing p27 binding. In cancer cells, the compound induces p27 accumulation and promotes cell type-specific blocks in G1 or G2/M phases.

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