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SKLB610

A potent angiogenesis inhibitor
Catalog #: 2610
SKU-Size Size Price Qty
2610-5 5 mg
$85.00
2610-25 25 mg
$335.00
More Sizes Get Quote

Product Details

Alternate Name N-Methyl-4-(4-(3-(trifluoromethyl)benzamido)phenoxy)picolinamide
Appearance White solid
CAS # 1125780-41-7
Molecular Formula C₂₁H₁₆F₃N₃O₃
Molecular Weight 415.36
Purity >98% by HPLC
Solubility DMSO
SMILES O=C(NC1=CC=C(OC2=CC=NC(C(NC)=O)=C2)C=C1)C3=CC=CC(C(F)(F)F)=C3
InChi InChI=1S/C21H16F3N3O3/c1-25-20(29)18-12-17(9-10-26-18)30-16-7-5-15(6-8-16)27-19(28)13-3-2-4-14(11-13)21(22,23)24/h2-12H,1H3,(H,25,29)(H,27,28)
InChi Key WACDHHMEVMSODJ-UHFFFAOYSA-N
Handling Protect from air and light
Storage Conditions -20 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

SKLB610 is a VEGFR inhibitor that potently suppresses human tumor angiogenesis. SKLB610 inhibits angiogenesis-related tyrosine kinase VEGFR2, fibroblast growth factor receptor 2 (FGFR2) and platelet-derived growth factor receptor (PDGFR) at rate of 97%, 65% and 55%, respectively, at concentration of 10 μM in biochemical kinase assays.SKLB610 exhibits its antitumor activity as a multi-targeted inhibitor with more potent inhibition of VEGFR2 activity.


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