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SKF-86002

A p38 MAP kinase inhibitor
Catalog #: 2894
SKU-Size Size Price Qty
2894-5 5 mg
$145.00
2894-25 25 mg
$565.00
More Sizes Get Quote

Product Details

Alternate Name 6-(4-Fluorophenyl)-5-(4-pyridyl)-2,3-dihydroimidazo[2,1-b]-thiazole
Appearance Off-white solid
CAS # 72873-74-6
Molecular Formula C₁₆H₁₂F₃FS
Molecular Weight 297.35
Purity ≥98% by HPLC
Solubility DMSO (>10 mg/ml)
SMILES C1CSC2=NC(=C(N21)C3=CC=NC=C3)C4=CC=C(C=C4)F
InChi InChI=1S/C16H12FN3S/c17-13-3-1-11(2-4-13)14-15(12-5-7-18-8-6-12)20-9-10-21-16(20)19-14/h1-8H,9-10H2
InChi Key YOELZIQOLWZLQC-UHFFFAOYSA-N
PubChem CID 5228
MDL Number MFCD00869367
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

SKF-86002 is a p38 MAP kinase inhibitor (IC₅₀ = 0.1 - 1 μM). Potently inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC₅₀ = 1 μM). Also acts as an inhibitor of both cyclooxygenase (COX) and 5-lipoxygenase (5-LO).


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