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Product Details
| Cat # +Size | 7578-10 |
|---|---|
| Size | 10 μg |
| Alternate Name | SIRT6, NAD-dependent Deacetylase Sirtuin-6; Mono-ADP-ribosyltransferase Sirtuin 6; SIR2-like Protein 6; SIR2L6 |
| Gene Symbol | SIRT6 |
| Gene ID | 51548 |
| Accession # | Q8N6T7 |
| Source | E. coli |
| Appearance | Liquid |
| Physical Form Description | 0.2 μm-filtered solution in 55 mM Tris-Cl, pH 8.2, containing 150 mM NaCl. |
| Molecular Weight | ~45.0 kDa. Human sirtuin 6 (aa 1-355) is fused at the N-terminus to a His-tag. |
| Purity by SDS-PAGE | ≥90% |
| Endotoxin Level | <0.1 EU/μg by LAL method |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not to be used in humans |
Details
Sirtuin 6 (SIRT6) is a NAD-dependent protein deacetylase with activity towards 'Lys-9' and 'Lys-56' of histone H3. It modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. It is required for genomic stability and for normal IGF1 serum levels and normal glucose homeostasis. It also regulates cellular senescence and apoptosis. Unlike most sirtuins, SIRT6 preferentially removes long-chain fatty-acyl, rather than acetyl, protein modifications. This activity regulates secretion of the inflammation-associated protein TNF-α.
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