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Sirtuin 2, human recombinant

A NAD-dependent deacetylase
Catalog #: 7632
SKU-Size Size Price Qty
7632-20 20 μg
$175.00
7632-100 100 μg
$375.00
7632-1000 1 mg
$3,000.00
More Sizes Get Quote

Product Details

Alternate Name NAD-dependent protein deacetylase sirtuin-2, Regulatory protein SIR2 homolog 2, SIR2-like protein 2
Gene Symbol SIRT2
Gene ID 22933
Accession # Q8IXJ6
Source E. coli
Appearance Liquid
Physical Form Description rh-Sirtuin 2 (SIRT2) with the native N-terminus is supplied as a liquid of 2 mg/ml in 25 mM Tris, pH 7.5, 100 mM NaCl, 2.7 mM KCl, 3 mM MgCl2, 10 % glycerol.
Molecular Weight 43 kDa
Purity by SDS-PAGE ≥90%
Biological Activity Activity of SIRT2 was tested using the substrate Arg-His-Lys-Lys(Ac)-AFC, which is a fluorogenic, acetylated peptide based on residues 379-382 of p53.
Handling Centrifuge the vial prior to opening.
Storage Conditions -70°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not to be used in humans

Details

Human sirtuins function as intracellular regulatory proteins. Sirtuin 2 is a member of the class III histone deacetylases (HDACs) and has been implicated in many cellular processes that include histone deacetylation, gene silencing, chromosomal stability, and aging. The enzymatic activity of class III HDACs is nicotinamide adenine dinucleotide (0.1mM NAD+) dependent and insensitive to HDAC inhibitor trichostatin A.


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