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Product Details
| Alternate Name | 2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]-N-(1-phenethyl)benzamide; Sir Two Inhibitor Naphthol |
|---|---|
| Appearance | Yellow solid |
| CAS # | 410536-97-9 |
| Molecular Formula | C₂₆H₂₂N₂O₂ |
| Molecular Weight | 394.47 |
| Purity | ≥98% |
| Solubility | DMSO (100 mM) |
| SMILES | CC(C1=CC=CC=C1)NC(=O)C2=CC=CC=C2NC=C3C(=O)C=CC4=CC=CC=C43 |
| InChi | InChI=1S/C26H22N2O2/c1-18(19-9-3-2-4-10-19)28-26(30)22-13-7-8-14-24(22)27-17-23-21-12-6-5-11-20(21)15-16-25(23)29/h2-18,27H,1H3,(H,28,30)/b23-17- |
| InChi Key | YUGODMKHHCZZOI-QJOMJCCJSA-N |
| PubChem CID | 5717148 |
| MDL Number | MFCD00810186 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Cell-permeable. A selective sirtuin deacetylase inhibitor with IC50 values of 38, 68 and 131 μM for SIRT2, Sir2p and SIRT1 respectively. Sirtinol has no effect on HDAC1 activity. Sirtinol inhibits the growth of cancer cells and suppresses inflammatory signaling in human dermal microvascular endothelial cells.
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