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Sirtinol

A selective sirtuin deacetylase inhibitor
Catalog #: 2062
SKU-Size Size Price Qty
2062-1 1 mg
$60.00
2062-5 5 mg
$235.00
More Sizes Get Quote

Product Details

Alternate Name 2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]-N-(1-phenethyl)benzamide; Sir Two Inhibitor Naphthol
Appearance Yellow solid
CAS # 410536-97-9
Molecular Formula C₂₆H₂₂N₂O₂
Molecular Weight 394.47
Purity ≥98%
Solubility DMSO (100 mM)
SMILES CC(C1=CC=CC=C1)NC(=O)C2=CC=CC=C2NC=C3C(=O)C=CC4=CC=CC=C43
InChi InChI=1S/C26H22N2O2/c1-18(19-9-3-2-4-10-19)28-26(30)22-13-7-8-14-24(22)27-17-23-21-12-6-5-11-20(21)15-16-25(23)29/h2-18,27H,1H3,(H,28,30)/b23-17-
InChi Key YUGODMKHHCZZOI-QJOMJCCJSA-N
PubChem CID 5717148
MDL Number MFCD00810186
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell-permeable. A selective sirtuin deacetylase inhibitor with IC50 values of 38, 68 and 131 μM for SIRT2, Sir2p and SIRT1 respectively. Sirtinol has no effect on HDAC1 activity. Sirtinol inhibits the growth of cancer cells and suppresses inflammatory signaling in human dermal microvascular endothelial cells.


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