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SirtACt

A potent SIRT1 activator
Catalog #: 2741
SKU-Size Size Price Qty
2741-2 2 mg
$95.00
2741-10 10 mg
$375.00
More Sizes Get Quote

Product Details

Alternate Name 2-​Amino-​N-​cyclopentyl-​1-​(3-​methoxypropyl)-​1H-​pyrrolo[2,​3-​b]quinoxaline-​3-​carboxamide; CAY10591; SIRT1 activator 3; Sirtuin1 Activator 3
Appearance Olive green solid
CAS # 839699-72-8
Molecular Formula C₂₀H₂₅N₅O₂
Molecular Weight 367.5
Purity ≥98% by TLC
Solubility DMSO (50 mg/ml) or EtOH (20 mg/ml, warm)
SMILES COCCCN1C(=C(C2=NC3=CC=CC=C3N=C21)C(=O)NC4CCCC4)N=N
InChi InChI=1S/C20H24N6O2/c1-28-12-6-11-26-18(25-21)16(20(27)22-13-7-2-3-8-13)17-19(26)24-15-10-5-4-9-14(15)23-17/h4-5,9-10,13,21H,2-3,6-8,11-12H2,1H3,(H,22,27)
InChi Key FCSPEKABVJVYEG-UHFFFAOYSA-N
PubChem CID 35028109
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

SirtAct is a potent Sirtuin 1 (SIRT1) activator. It increases fluorescence by 233% in a SIRT1 activity assay. SIRT1 stimulation by SirtAct leads to decreased tissue factor mediated thrombogenicity in mice. It inhibits NF-κB activation and reduces inflammatory cytokine production in lamina propria mononuclear cells from IBD patients. SirtAct also prevents and cures experimental colitis in a mouse model.


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