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Product Details
| Cat # +Size | 6107-50 |
|---|---|
| Size | 50 μg |
| Antibody Target | SIRT7 |
| Alternate Name | SIR2; Sirtuin 7; Silent Information Regulator 7 |
| Host | Rabbit |
| Antibody Type | Polyclonal |
| Isotype | Rabbit IgG |
| Immunogen | Human SIRT7 aa 35-51 and 361-377 |
| Accession # | Q9NRC8 |
| Gene ID | 51547 |
| Appearance | Colorless liquid |
| Formulation | 50 µg of antibody in 100 µl PBS containing 0.2% gelatin and 0.05% sodium azide |
| Purification | Protein G purified |
| Species Reactivity | Human |
| Application | Western blot |
| Positive Control | Western blot: Human liver homogenate, PBMC lysate |
| Application & Usage | Western blot: 1-3 µg/ml. However, the optimal conditions should be determined individually. |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | -20 °C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs) and have been shown to catalyze a reaction that couples lysine deacetylation to the formation of nicotinamide and O-acetyl-ADP-ribose from NAD+ and the abstracted acetyl group. SIRT7 is a member of this family of proteins and is present in prokaryotes and eukaryotes. All SIR2-like proteins have a sirtuin core domain, which contains a series of sequence motifs conserved in organisms ranging from bacteria to humans. Bacterial, yeast, and mammalian sirtuins are able to metabolize NAD+ and several act as mono-ADP-ribosyltransferases. The enzymatic function of sirtuins is not yet completely understood but as mentioned above, recent reports of histone-activated SIR2-mediated NAD+ metabolism and NAD+-activated SIR2-mediated histone deacetylation sμggest a possible coupled reciprocal activation mechanism involving interactions of SIR2 with NAD+ and the N-ε-acetyl-lysine groups of acetylated histone.
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