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SIRT7 Antibody

Polyclonal antibody to detect SIRT7 (a lysyl-deacetylase) in human samples
Catalog #: 6107
$205.00

Product Details

Cat # +Size 6107-50
Size 50 μg
Antibody Target SIRT7
Alternate Name SIR2; Sirtuin 7; Silent Information Regulator 7
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Human SIRT7 aa 35-51 and 361-377
Accession # Q9NRC8
Gene ID 51547
Appearance Colorless liquid
Formulation 50 µg of antibody in 100 µl PBS containing 0.2% gelatin and 0.05% sodium azide
Purification Protein G purified
Species Reactivity Human
Application Western blot
Positive Control Western blot: Human liver homogenate, PBMC lysate
Application & Usage Western blot: 1-3 µg/ml. However, the optimal conditions should be determined individually.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs) and have been shown to catalyze a reaction that couples lysine deacetylation to the formation of nicotinamide and O-acetyl-ADP-ribose from NAD+ and the abstracted acetyl group. SIRT7 is a member of this family of proteins and is present in prokaryotes and eukaryotes. All SIR2-like proteins have a sirtuin core domain, which contains a series of sequence motifs conserved in organisms ranging from bacteria to humans. Bacterial, yeast, and mammalian sirtuins are able to metabolize NAD+ and several act as mono-ADP-ribosyltransferases. The enzymatic function of sirtuins is not yet completely understood but as mentioned above, recent reports of histone-activated SIR2-mediated NAD+ metabolism and NAD+-activated SIR2-mediated histone deacetylation sμggest a possible coupled reciprocal activation mechanism involving interactions of SIR2 with NAD+ and the N-ε-acetyl-lysine groups of acetylated histone.


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