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Product Details
| Alternate Name | NAD-dependent deacetylase 7; SIR2-like protein 7; Sirtuin 7; SIR2L7; Silent Information Regulator 7 |
|---|---|
| Gene Symbol | SIRT7 |
| Gene ID | 51547 |
| Accession # | Q9NRC8 |
| Source | E. coli |
| Appearance | Liquid |
| Physical Form Description | 50 mM sodium phosphate, pH 7.2, 100 mM sodium chloride, 5 mM DTT, and 20% glycerol. |
| Molecular Weight | 49.3 kDa (2-400 aa, NT His Tag) |
| Purity by SDS-PAGE | ≥85% |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -80°C |
| Shipping Conditions | Dry Ice |
| USAGE | For Research Use Only! Not to be used in humans |
Details
The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs) and have been shown to catalyze a reaction that couples lysine deacetylation to the formation of nicotinamide and O-acetyl-ADP-ribose from NAD+ and the abstracted acetyl group. There are seven human sirtuins, which have been designated SIRT1-SIRT7. Recently, SIRT7 has been shown to activate transcription by RNA polymerase I and deacetylate p53. SIRT7 prevents progressive functional deterioration of the heart, and is suggested to play an important role in regulation of stress responses and cell death in the heart.
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