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SIRT7 (2-400 aa) (His-tagged), Human recombinant

Intracellular regulatory proteins with mono-ADP-ribosyltransferase activity.
Catalog #: 7675
SKU-Size Size Price Qty
7675-20 20 μg
$145.00
7675-50 50 μg
$295.00
More Sizes Get Quote

Product Details

Alternate Name NAD-dependent deacetylase 7; SIR2-like protein 7; Sirtuin 7; SIR2L7; Silent Information Regulator 7
Gene Symbol SIRT7
Gene ID 51547
Accession # Q9NRC8
Source E. coli
Appearance Liquid
Physical Form Description 50 mM sodium phosphate, pH 7.2, 100 mM sodium chloride, 5 mM DTT, and 20% glycerol.
Molecular Weight 49.3 kDa (2-400 aa, NT His Tag)
Purity by SDS-PAGE ≥85%
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not to be used in humans

Details

The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs) and have been shown to catalyze a reaction that couples lysine deacetylation to the formation of nicotinamide and O-acetyl-ADP-ribose from NAD+ and the abstracted acetyl group. There are seven human sirtuins, which have been designated SIRT1-SIRT7. Recently, SIRT7 has been shown to activate transcription by RNA polymerase I and deacetylate p53. SIRT7 prevents progressive functional deterioration of the heart, and is suggested to play an important role in regulation of stress responses and cell death in the heart.


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