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SIRT6 Antibody

Polyclonal Antibody to detect Sirt6 in human and Mouse samples
Catalog #: 6692
SKU-Size Size Price Qty
6692-30T 30 µg
$89.00
6692-100 100 μg
$265.00
More Sizes Get Quote

Product Details

Antibody Target SIRT6
Alternate Name SIRT6, NAD-dependent Deacetylase Sirtuin-6; Mono-ADP-ribosyltransferase Sirtuin 6; SIR2-like Protein 6; SIR2L6
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Recombinant Human Sirtuin 6 (Cat # 7699)
Accession # Q8N6T7
Gene ID 51548
Appearance Colorless liquid
Concentration 0.5 mg/ml
Formulation 100 µg (0.5 mg/ml) of antibody in PBS pH 7.2, 0.01 % BSA, 0.03 % ProClin®, and 50 % glycerol.
Purification Affinity Purified Antibody
Species Reactivity Human, Mouse
Application Western blot
Positive Control Western Blot: Jurkat cell lysate, mouse muscle lysate, Rat kidney lysate, Recombinant proteins
Application & Usage Western blot: 1-4 µg
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Human Sirtuins function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. Sirtuin 6 (SIRT6) is a NAD-dependent protein deacetylase with activity towards Lys-9 and Lys-56 of histone H3. It modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. It is required for genomic stability and for normal IGF1 serum levels and normal glucose homeostasis. It also regulates cellular senescence and apoptosis. Unlike most sirtuins, SIRT6 preferentially removes long-chain fatty-acyl, rather than acetyl, protein modifications. This activity regulates secretion of the inflammation-associated protein TNF-α.


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