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Product Details
| Alternate Name | NAD-dependent Deacetylase 5; SIR2-like Protein 5; SIR2L5; Sirtuin 5; Silent Information Regulator 5 |
|---|---|
| Gene Symbol | SIRT5 |
| Gene ID | 23408 |
| Accession # | Q9NXA8 |
| Source | E. coli |
| Appearance | Liquid |
| Physical Form Description | 50 mM sodium phosphate, pH 7.2, 100 mM sodium chloride, and 20% glycerol. |
| Molecular Weight | 60.6 kDa (NT GST Tag), 26 kDa (native) |
| Purity by SDS-PAGE | ≥90% |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -80°C |
| Shipping Conditions | Dry Ice |
| USAGE | For Research Use Only! Not to be used in humans |
Details
The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs) and have been shown to catalyze a reaction that couples lysine deacetylation to the formation of nicotinamide and O-acetyl-ADP-ribose from NAD+ and the abstracted acetyl group. There are seven human sirtuins, which have been designated SIRT1-7. SIRT5 is located in the mitochondrial matrix and its functions are largely still being elucidated, however a few promising substrates have been studied. SIRT5 has been shown to deacetylate carbamoyl phosphate synthetase 1 (CSP1), activating the enzyme to catalyze the first step of the urea cycle. CSP1 is important in the detoxification of excess ammonia that can accumulate during fasting. Cytochrome C, another mitochondrial enzyme involved in oxidative metabolism can also be deacetylated by SIRT5. SIRT5 is predominantly found in the heart, brain, testis, and lymphoblasts.
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