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SIRT2 Inhibitor, B2

A potent SIRT2 inhibitor
Catalog #: 2085
$175.00

Product Details

Cat # +Size 2085-5
Size 5 mg
Alternate Name 5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline, CPNQ
Appearance Yellow solid
CAS # 115687-05-3
Molecular Formula C₂₀H₁₇ClN₄O₃
Molecular Weight 396.83
Purity ≥95%
Solubility DMSO (>5 mg/ml)
SMILES C1CN(CCN1C2=C3C=CC=NC3=C(C=C2)[N+](=O)[O-])C(=O)C4=CC=C(C=C4)Cl
InChi InChI=1S/C20H17ClN4O3/c21-15-5-3-14(4-6-15)20(26)24-12-10-23(11-13-24)17-7-8-18(25(27)28)19-16(17)2-1-9-22-19/h1-9H,10-13H2
InChi Key KLNPVNZJCWIQSK-UHFFFAOYSA-N
PubChem CID 3953303
MDL Number MFCD02039810
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell-permeable. A Sirtuin 2 (SIRT2) inhibitor (IC50 = 35 µM). Promotes inclusion formation in cellular models of both Huntington’s disease and Parkinson’s disease. Prevents huntingtin-mediated proteasome dysfunction and reduces α-synuclein-mediated toxicity.


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