SIRT2 Inhibitor, AGK2

A SIRT2 inhibitor
Catalog #: 1651 | abID: ab142073

Product Details

abID ab142073
Cat # +Size 1651-10
Size 10 mg
Alternate Name AGK2, (2E)-2-cyano-3-[5-(2,5-dichlorophenyl)furan-2-yl]-N-(quinolin-5-yl)prop-2-enamide
Appearance Yellow solid
CAS # 304896-28-4
Molecular Formula C₂₃H₁₃Cl₂N₃O₂
Molecular Weight 434.27
Purity ≥95% by HPLC
Solubility DMSO
SMILES C1=CC2=C(C=CC=N2)C(=C1)NC(=O)C(=CC3=CC=C(O3)C4=C(C=CC(=C4)Cl)Cl)C#N
InChi InChI=1S/C23H13Cl2N3O2/c24-15-6-8-19(25)18(12-15)22-9-7-16(30-22)11-14(13-26)23(29)28-21-5-1-4-20-17(21)3-2-10-27-20/h1-12H,(H,28,29)/b14-11+
PubChem CID 2130404
MDL Number MFCD01909444
Handling Protect from air and light
Storage Conditions 4°C
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.


A potent inhibitor of sirtuin 2 (SIRT2) (IC₅₀ = 3.5 µM). AGK2 is >15-fold more selective for SIRT2 than SIRT1 and SIRt3. Inhibition of SIRT2 rescued α-synuclein toxicity and modified inclusion morphology in a cellular model of Parkinson’s disease.

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