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SIRT2 Antibody

Polyclonal antibody to detect SIRT2 in human, mouse and rat samples.
Catalog #: 6138
$335.00

Product Details

Cat # +Size 6138-100
Size 100 μg
Antibody Target SIRT2
Alternate Name SIRT2, SIR2, SIR2L, SIR2L2
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen C terminal peptide of human SIRT2
Accession # Q8IXJ6
Gene ID 22933
Appearance Colorless liquid
Formulation 100 µg of antibody in 100 µl PBS containing 0.02% sodium azide, 50% glycerol, pH 7.3
Purification Affinity purified
Species Reactivity Human, mouse, rat
Application Western blot, Immunohistochemistry
Positive Control Western Blot: Brain tissue extracts
Application & Usage Western blot: 1:500 – 1:2000 dilution, IHC: 1:50 - 1:200 dilution. However, the optimal conditions should be determined individually.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs) and have been shown to catalyze a reaction that couples lysine deacetylation to the formation of nicotinamide and O-acetyl-ADP-ribose from NAD+ and the abstracted acetyl group. This SIRT family of genes is highly conserved from prokaryotes to eukaryotes and is involved in diverse processes including transcriptional regulation, cell cycle progression, DNA damage repair and aging. SIRT2, a human homolog of the yeast SIR2 (silent information regulator­2), functions as transcriptional silencing mediator at mating­type loci, telomeres and ribosomal gene clusters. SIRT2 expression increases dramatically during mitosis and is multiply phosphorylated at the G (2)/M transition of the cell cycle. SIRT2 is part of a phosphorylation cascade where it is phosphorylated late in G (2), during M, and into the period of cytokinesis. Inhibition of SIRT2 is reported to rescue alpha­synuclein toxicity and modify inclusion morphology in a cellular model of Parkinson's disease.


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