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SIRT1 Inhibitor, EX-527

A SIRT1 inhibitor
Catalog #: 1652

In stock

$165.00

Product Details

Cat # +Size 1652-10
Size 10 mg
Alternate Name EX-527, 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
Appearance White solid
CAS # 49843-98-3
Molecular Formula C₁₃H₁₃ClN₂O
Molecular Weight 248.71
Purity ≥97% by HPLC
Solubility DMSO (20 mg/ml)
SMILES C1CC(C2=C(C1)C3=C(N2)C=CC(=C3)Cl)C(=O)N
InChi InChI=1S/C13H13ClN2O/c14-7-4-5-11-10(6-7)8-2-1-3-9(13(15)17)12(8)16-11/h4-6,9,16H,1-3H2,(H2,15,17)
InChi Key FUZYTVDVLBBXDL-UHFFFAOYSA-N
PubChem CID 5113032
MDL Number MFCD03009471
Handling Protect from air and light
Storage Conditions 4°C
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

A potent SIRT1 inhibitor (IC₅₀ = 38 nM). EX-527 is 200-500-fold more selective for SIRT1 than for SIRT2 or SIRT3. Does not inhibit SIRT4-7, does not inhibit class I/II HDAC activity at concentrations up to 100µM. Enhances p53 acetylation in response to DNA damaging agents.


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