Product Details
| Alternate Name | Lu-28-179; 1'-[4-[1-(4-fluorophenyl)indol-3-yl]butyl]spiro[1H-2-benzofuran-3,4'-piperidine]; 1'-(4-(1-(p-Fluorophenyl)indol-3-yl)butyl)spiro(phthalan-1,4'-piperidine) |
|---|---|
| Appearance | White solid |
| CAS # | 147817-50-3 |
| Molecular Formula | C₃₀H₃₁FN₂O |
| Molecular Weight | 454.6 |
| Purity | ≥98% |
| Solubility | ~25 mg/ml in DMSO |
| SMILES | C1CN(CCC12C3=CC=CC=C3CO2)CCCCC4=CN(C5=CC=CC=C54)C6=CC=C(C=C6)FInChi:InChI=1S/C30 |
| InChi | InChI=1S/C30H31FN2O/c31-25-12-14-26(15-13-25)33-21-23(27-9-2-4-11-29(27)33)7-5-6-18-32-19-16-30(17-20-32)28-10-3-1-8-24(28)22-34-30/h1-4,8-15,21H,5-7,16-20,22H2 |
| InChi Key | XWAONOGAGZNUSF-UHFFFAOYSA-N |
| PubChem CID | 9829526 |
| MDL Number | MFCD00912182 |
| Handling | Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure. |
| Storage Conditions | -20ºC |
| Shipping Conditions | RT |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Siramesine is an agonist for sigma-2 (σ2) receptor. It is selective for σ2 over σ1 with IC₅₀ values of 0.12 nM and 17 nM respectively. It shows potent anxiolytic-like effects in rodents. The minimal effective dose (MED) is 0.18 nmol/kg (0.1 microg/kg) and 0.00018 nmol/kg (0.1 ng/kg) in rats and mice respectively. It (20-30 μM) induces cell death in HaCaT, Hsc-4, HeLa, MCF-7, SH-SY5Y and glioblastoma cell lines. Siramesine shows anti-viral activity againt SARS-CoV-2 infection in the Vero E6 cell line in an immunofluorescence-based assay (detecting the viral NP protein).
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