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Sildenafil citrate

A potent phosphodiesterase 5 (PDE5) inhibitor
Catalog #: 2872
SKU-Size Size Price Qty
2872-10 10 mg
2872-50 50 mg
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Product Details

Alternate Name 1-[[3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine citrate
Appearance White solid
CAS # 171599-83-0
Molecular Formula C₂₂H₃₀N₆O₄S.C₆H₈O₇
Molecular Weight 666.71
Purity ≥98% by HPLC
Solubility DMSO (~25 mg/ml)
InChi InChI=1S/C22H30N6O4S.C6H8O7/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28;7-3(8)1-6(13,5(11)12)2-4(9)10/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29);13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
PubChem CID 62853
MDL Number MFCD09026931
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Sildenafil citrate is a potent, orally active phosphodiesterase 5 (PDE5) inhibitor (IC₅₀ = 4 nM). Inhibition of PDE5 enhances the relaxation of smooth muscle in a range of vascular tissues by prolonging the nitric oxide/cGMP-mediated activation of cGMP-dependent protein kinase (PKG). Sildenafil also acts as a vasodilator and this property has been used to control vascular tone in pulmonary arterial hypertension and high-altitude pulmonary edema associated with altitude sickness.

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