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SHP-2, Human Recombinant

Activates Erk/MAP kinase pathway by receptor tyrosine kinase signaling.
Catalog #: P1560
SKU-Size Size Price Qty
P1560-10 10 μg
P1560-50 50 μg
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Product Details

Alternate Name PTPN11, Tyrosine-protein phosphatase non-receptor type 11, Protein-tyrosine phosphatase 1D, PTP-1D, Protein-tyrosine phosphatase 2C, PTP-2C, SH-PTP2, SH-PTP3, BPTP3, CFC, JMML, METCDS, NS1, SHP-2, shp-2, PTP2C, SHPTP2
Gene Symbol PTPN11
Gene ID 5781
Accession # Q06124
Source HEK 293 cells
Appearance Liquid
Physical Form Description Liquid
Molecular Weight 69.1 kDa ( His-tag at C-terminus)
Purity by SDS-PAGE >90%
Endotoxin Level < 1 EU per 1ug of protein (determined by LAL method)
Biological Activity Specific activity is > 400 unit/mg
Amino Acid Sequence aa 602 (1-593 aa)
Handling Centrifuge the vial prior to opening.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


SHP-2, also known as, tyrosine-protein phospatase non-receptor type 11(PTPN11), is a member of the protein tyrosine phosphatase (PTP) family containing two Src homology 2 domains. This protein dephosphorylation tyrosine residues in proteins. It plays a stimulatory role in the activation of the Erk/MAP kinase pathway by receptor tyrosine kinase signaling. Mutations in this protein are a cause of Noonan syndrome as well as acute myeloid leukemia. Recombinant human SHP-2, fused to His-tag at C-terminus, was expressed in an insect cell and purified by using conventional chromatography techniques.

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