Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]

New

SHP-2, Human Recombinant

Activates Erk/MAP kinase pathway by receptor tyrosine kinase signaling.
Catalog #: P1560
SKU-Size Size Price Qty
P1560-10 10 μg
$125.00
P1560-50 50 μg
$495.00
More Sizes Get Quote

Product Details

Alternate Name PTPN11, Tyrosine-protein phosphatase non-receptor type 11, Protein-tyrosine phosphatase 1D, PTP-1D, Protein-tyrosine phosphatase 2C, PTP-2C, SH-PTP2, SH-PTP3, BPTP3, CFC, JMML, METCDS, NS1, SHP-2, shp-2, PTP2C, SHPTP2
Gene Symbol PTPN11
Gene ID 5781
Accession # Q06124
Source HEK 293 cells
Appearance Liquid
Physical Form Description Liquid
Molecular Weight 69.1 kDa ( His-tag at C-terminus)
Purity by SDS-PAGE >90%
Endotoxin Level < 1 EU per 1ug of protein (determined by LAL method)
Biological Activity Specific activity is > 400 unit/mg
Amino Acid Sequence aa 602 (1-593 aa)
Handling Centrifuge the vial prior to opening.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

SHP-2, also known as, tyrosine-protein phospatase non-receptor type 11(PTPN11), is a member of the protein tyrosine phosphatase (PTP) family containing two Src homology 2 domains. This protein dephosphorylation tyrosine residues in proteins. It plays a stimulatory role in the activation of the Erk/MAP kinase pathway by receptor tyrosine kinase signaling. Mutations in this protein are a cause of Noonan syndrome as well as acute myeloid leukemia. Recombinant human SHP-2, fused to His-tag at C-terminus, was expressed in an insect cell and purified by using conventional chromatography techniques.


Why buy BioVision Products?
Innovation
Affordability
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.