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A Pim kinase inhibitor
Catalog #: 2554
SKU-Size Size Price Qty
2554-5 5 mg
2554-25 25 mg
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Product Details

Alternate Name N-[(1-Methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-6-amine
Appearance White to off-white solid
CAS # 1025065-69-3
Molecular Formula C₂₀H₂₂F₃N₅O
Molecular Weight 405.42
Purity ≥98% by HPLC
Solubility DMSO (>75 mg/ml)
InChi InChI=1S/C20H22F3N5O/c1-27-9-7-14(8-10-27)12-24-18-5-6-19-25-13-17(28(19)26-18)15-3-2-4-16(11-15)29-20(21,22)23/h2-6,11,13-14H,7-10,12H2,1H3,(H,24,26)
PubChem CID 24795070
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


SGI-1776 is a potent and ATP-competitive Pim kinase inhibitor (IC₅₀’s = 7, 363, and 69 nM for Pim-1, Pim-2 and Pim-3, respectively). SGI-1776 also inhibits FLT3 (IC₅₀ = 44 nM). Induces apoptosis in chronic lymphocytic leukemia cells.

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