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SGI-1027

A selective DNA methyltransferase (DNMT) inhibitor
Catalog #: 2726
SKU-Size Size Price Qty
2726-5 5 mg
$125.00
2726-25 25 mg
$495.00
More Sizes Get Quote

Product Details

Alternate Name N-[4-[(2-Amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)benzamide
Appearance Off-white solid
CAS # 1020149-73-8
Molecular Formula C₂₇H₂₃N₇O
Molecular Weight 461.52
Purity ³98%
Solubility DMSO (~20 mg/ml)
SMILES CC1=CC(=NC(=N1)N)NC2=CC=C(C=C2)NC(=O)C3=CC=C(C=C3)NC4=CC=NC5=CC=CC=C54
InChi InChI=1S/C27H23N7O/c1-17-16-25(34-27(28)30-17)32-20-10-12-21(13-11-20)33-26(35)18-6-8-19(9-7-18)31-24-14-15-29-23-5-3-2-4-22(23)24/h2-16H,1H3,(H,29,31)(H,33,35)(H3,28,30,32,34)
InChi Key QSYLKMKIVWJAAK-UHFFFAOYSA-N
PubChem CID 24858111
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

SGI-1027 is a selective DNA methyltransferase (DNMT) inhibitor. Inhibits DNMT1, DNMT3A, and DNMT3B with IC₅₀ values of 6, 8, and 7.5 µM, respectively. Treatment of different cancer cell lines with SGI-1027 results in selective degradation of DNMT1 with minimal or no effects on DNMT3A and DNMT3B


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