Product Details
| Alternate Name | 1-isoquinolin-6-yl-3-(2-oxo-2-pyrrolidin-1-ylethyl)urea; N-6-Isoquinolinyl-N'-[2-oxo-2-(1-pyrrolidinyl)ethyl]-urea; N-{2-[(2-Oxo-3-azepanyl)carbamoyl]phenyl}-1-benzothiophene-2-carboxamide |
|---|---|
| Appearance | A crystalline solid |
| CAS # | 1687736-54-4 |
| Molecular Formula | C₁₆H₁₈N₄O₂ |
| Molecular Weight | 298.34 |
| Purity | ≥98% |
| Solubility | ~2 mg/ml in DMSO and DMF ~5 mg/ml in Ethanol |
| SMILES | C1CCN(C1)C(=O)CNC(=O)NC2=CC3=C(C=C2)C=NC=C3 |
| InChi | InChI=1S/C16H18N4O2/c21-15(20-7-1-2-8-20)11-18-16(22)19-14-4-3-13-10-17-6-5-12(13)9-14/h3-6,9-10H,1-2,7-8,11H2,(H2,18,19,22) |
| InChi Key | DMIDPTCQPIJYFE-UHFFFAOYSA-N |
| PubChem CID | 90642938 |
| Handling | Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure. |
| Storage Conditions | -20ºC |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
SGC707 is a potent, selective and allosteric inhibitor of Protein arginine methyltransferase3 (PRMT3) with an IC₅₀ of 31 nM and KD of 53 nM. It inhibits the methylation of histones in cells at a concentration of 1 µM.
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