A potent DOT1L inhibitor
Catalog #: 2448 | abID:

Product Details

Alternate Name 1-[3-[[[(2R,3S,4R,5R)-5-(4-Amino-5-​bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydro​xytetrahydrofuran-2-yl]methyl](isopropyl)amino]pro​pyl]-3-[4-(2,2-dimethylethyl)phenyl]urea
Appearance White solid
CAS # 1561178-17-3
Molecular Formula C₂₈H₄₀BrN₇O₄
Molecular Weight 618.57
Purity ≥98% by HPLC
Solubility DMSO (> 50 mg/ml) or EtOH (>50 mg/ml)
InChi InChI=1S/C28H40BrN7O4/c1-16(2)35(12-6-11-31-27(39)34-18-9-7-17(8-10-18)28(3,4)5)14-20-22(37)23(38)26(40-20)36-21(29)13-19-24(30)32-15-33-25(19)36/h7-10,13,15-16,20,22-23,26,37-38H,6,11-12,14H2,1-5H3,(H2,30,32,33)(H2,31,34,39)/t20-,22-,23-,26-/m1/s1
PubChem CID 71729976
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


A potent and selective DOT1L inhibitor (IC₅₀ = 0. 3 nM in a radioactive enzyme assay); >100-fold selective for other histone methyltransferases (HMTs). SGC0946 also potently reduces H3K79 dimethylation with cellular IC₅₀ of 2.6 nM in A431 cells, and 8.8 nM in MCF10A cells.

Why buy BioVision Products?
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.