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Product Details
| Alternate Name | (4R,7S,10S,13R,16S,19R,22R)-16-((1H-imidazol-5-yl)methyl)-7-((1H-indol-3-yl)methyl)-22-((S)-2-acetamido-
5-guanidinopentanamido)-13-benzyl-10-(3-guanidinopropyl)-19-methyl-6,9,12,15,18,21-hexaoxo-1,2-dithia-5,8,11,14,17,20-
hexaazacyclotricosane-4-carboxamide diacetic acid; Ac-Arg-Cys(1)-D-Ala-His-D-Phe-Arg-Trp-Cys(1)-NH2.2CH3CO2H; RM-493 acetate; BIM-22493 acetate; IRC-022493 acetate |
|---|---|
| Appearance | White to off-white solid powder |
| CAS # | 1504602-49-6 |
| Molecular Formula | C₅₃H₇₆N₁₈O₁₃S₂ |
| Molecular Weight | 1237.41 |
| Purity | ≥ 98% |
| Solubility | Soluble in DMSO |
| SMILES | CC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)N1)NC(=O)C(CCCN=C(N)N) NC(=O)C)C(=O)N)CC2=CNC3=CC=CC=C32)CCCN=C(N)N)CC4=CC=CC=C4)CC5=CN=CN5.CC(=O) O.CC(=O)O |
| InChi | InChI=1S/C49H68N18O9S2.2C2H4O2/c1-26-41(70)63-37(20-30-22-55-25-59-30)46(75)64-35 (18-28-10-4-3-5-11-28)44(73)62-34(15-9-17-57-49(53)54)43(72)65-36(19-29-21-58-32-13-7-6-12-31(29)32) 45(74)66-38(40(50)69)23-77-78-24-39(47(76)60-26)67-42(71)33(61-27(2)68)14-8-16-56-48(51)52;2*1-2(3)4/h3-7,10-13,21-22,25-26,33-39,58H,8-9,14-20,23-24H2,1-2H3,(H2,50,69)(H,55,59)(H,60,76)(H,61,68)(H,62,73)(H,63,70)(H,64,75)(H,65,72)(H,66,74)(H,67,71)(H4,51,52,56)(H4,53,54,57);2*1H3,(H,3,4)/t26-,33+,34+,35-,36+,37+,38+,39+;;/m1../s1 |
| InChi Key | GOOYENKUPOAYOV-KMKYJKQVSA-N |
| PubChem CID | 154731816 |
| Handling | Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure. |
| Storage Conditions | -20ºC |
| Shipping Conditions | RT |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Setmelanotide acetate is a selective melanocortin 4 receptor (MC4R) agonist. It shows EC₅₀ values of 0.27 nM and 0.28 nM for human and rat MC4R respectively. It causes weight loss, improves hyperinsulinemia and fatty liver in diet induced obese mice. It is approved for use in chronic weight management of obesity due to proopiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1 (PCSK1), or leptin receptor (LEPR) deficiency.
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