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Setmelanotide Acetate

A selective melanocortin 4 receptor (MC4R) agonist
Catalog #: B3098
SKU-Size Size Price Qty
B3098-1 1 mg
$115.00
B3098-5 5 mg
$385.00
More Sizes Get Quote

Product Details

Alternate Name (4R,7S,10S,13R,16S,19R,22R)-16-((1H-imidazol-5-yl)methyl)-7-((1H-indol-3-yl)methyl)-22-((S)-2-acetamido- 5-guanidinopentanamido)-13-benzyl-10-(3-guanidinopropyl)-19-methyl-6,9,12,15,18,21-hexaoxo-1,2-dithia-5,8,11,14,17,20- hexaazacyclotricosane-4-carboxamide diacetic acid;
Ac-Arg-Cys(1)-D-Ala-His-D-Phe-Arg-Trp-Cys(1)-NH2.2CH3CO2H; RM-493 acetate;
BIM-22493 acetate;
IRC-022493 acetate
Appearance White to off-white solid powder
CAS # 1504602-49-6
Molecular Formula C₅₃H₇₆N₁₈O₁₃S₂
Molecular Weight 1237.41
Purity ≥ 98%
Solubility Soluble in DMSO
SMILES CC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)N1)NC(=O)C(CCCN=C(N)N)
NC(=O)C)C(=O)N)CC2=CNC3=CC=CC=C32)CCCN=C(N)N)CC4=CC=CC=C4)CC5=CN=CN5.CC(=O)
O.CC(=O)O
InChi InChI=1S/C49H68N18O9S2.2C2H4O2/c1-26-41(70)63-37(20-30-22-55-25-59-30)46(75)64-35
(18-28-10-4-3-5-11-28)44(73)62-34(15-9-17-57-49(53)54)43(72)65-36(19-29-21-58-32-13-7-6-12-31(29)32) 45(74)66-38(40(50)69)23-77-78-24-39(47(76)60-26)67-42(71)33(61-27(2)68)14-8-16-56-48(51)52;2*1-2(3)4/h3-7,10-13,21-22,25-26,33-39,58H,8-9,14-20,23-24H2,1-2H3,(H2,50,69)(H,55,59)(H,60,76)(H,61,68)(H,62,73)(H,63,70)(H,64,75)(H,65,72)(H,66,74)(H,67,71)(H4,51,52,56)(H4,53,54,57);2*1H3,(H,3,4)/t26-,33+,34+,35-,36+,37+,38+,39+;;/m1../s1
InChi Key GOOYENKUPOAYOV-KMKYJKQVSA-N
PubChem CID 154731816
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

Setmelanotide acetate is a selective melanocortin 4 receptor (MC4R) agonist. It shows EC₅₀ values of 0.27 nM and 0.28 nM for human and rat MC4R respectively. It causes weight loss, improves hyperinsulinemia and fatty liver in diet induced obese mice. It is approved for use in chronic weight management of obesity due to proopiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1 (PCSK1), or leptin receptor (LEPR) deficiency.


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