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A potent inhibitor of phosphoinositide 3-kinase α (PI3Kα) inhibitor
Catalog #: B1930
SKU-Size Size Price Qty
B1930-5 5 mg
B1930-25 25 mg
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Product Details

Alternate Name  [6-(2-amino-5-benzoxazolyl)imidazo[1,2-a]pyridin-3-yl]-4-morpholinyl-methanone; MLN1117, INK1117, TAK-117)
Appearance Brown solid
CAS # 1268454-23-4 
Molecular Formula C₁₉H₁₇N₅O₃
Molecular Weight 363.34
Purity ≥98% by HPLC
Solubility DMSO (~1 mg/ml)
InChi InChI=1S/C19H17N5O3/c20-19-22-14-
PubChem CID 70798655
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Serabelisib is a potent inhibitor of phosphoinositide 3-kinase α (PI3Kα) that is selective for p110α in vitro (IC₅₀ = 15 nM for PI3Kα vs. >1 µM for other isoforms, as well as for mTOR). MLN1117 inhibits AKT phosphorylation and growth in PIK3CA mutant breast cancer cells with IC₅₀ values around 2 μM, yet has no effect on cells lacking PTEN. 

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