A potent γ-secretase inhibitor
Catalog #: 2430 | abID:

Product Details

Alternate Name (S)-2-hydroxy-3-methyl-N-((S)-1-((S)-3-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-ylamino)-1-oxopropan-2-yl)butanamide ; LY450139
Appearance White solid
CAS # 425386-60-3
Molecular Formula C₁₉H₂₇N₃O₄
Molecular Weight 361.44
Purity ≥98% by HPLC
Solubility DMSO (>60 mg/ml) or EtOH (>40 mg/ml)
InChi InChI=1S/C19H27N3O4/c1-11(2)16(23)18(25)20-12(3)17(24)21-15-14-8-6-5-7-13(14)9-10-22(4)19(15)26/h5-8,11-12,15-16,23H,9-10H2,1-4H3,(H,20,25)(H,21,24)/t12-,15-,16-/m0/s1
PubChem CID 9843750
Handling Protect from light and air
Storage Conditions -20 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


A potent γ-secretase inhibitor (IC₅₀ = 10.9 nM, 12.1 nM and 12.0 nM for Aβ42, Aβ40 and Aβ38, respectively). Semagacestat has shown to reduce the rate of formation of amyloid-β in vitro and in vivo.

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