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Product Details
| Alternate Name | (S)-2-hydroxy-3-methyl-N-((S)-1-((S)-3-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-ylamino)-1-oxopropan-2-yl)butanamide ; LY450139 |
|---|---|
| Appearance | White solid |
| CAS # | 425386-60-3 |
| Molecular Formula | C₁₉H₂₇N₃O₄ |
| Molecular Weight | 361.44 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (>60 mg/ml) or EtOH (>40 mg/ml) |
| SMILES | CC(C)C(C(=O)NC(C)C(=O)NC1C2=CC=CC=C2CCN(C1=O)C)O |
| InChi | InChI=1S/C19H27N3O4/c1-11(2)16(23)18(25)20-12(3)17(24)21-15-14-8-6-5-7-13(14)9-10-22(4)19(15)26/h5-8,11-12,15-16,23H,9-10H2,1-4H3,(H,20,25)(H,21,24)/t12-,15-,16-/m0/s1 |
| InChi Key | PKXWXXPNHIWQHW-RCBQFDQVSA-N |
| PubChem CID | 9843750 |
| Handling | Protect from light and air |
| Storage Conditions | -20 ̊C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
A potent γ-secretase inhibitor (IC₅₀ = 10.9 nM, 12.1 nM and 12.0 nM for Aβ42, Aβ40 and Aβ38, respectively). Semagacestat has shown to reduce the rate of formation of amyloid-β in vitro and in vivo.
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