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A RET kinase inhibitor
Catalog #: B2996
SKU-Size Size Price Qty
B2996-1 1 mg
B2996-5 5 mg
More Sizes Get Quote

Product Details

Alternate Name 6-(2-hydroxy-2-methylpropoxy)-4-[6-[6-[(6-methoxypyridin-3-yl)methyl]-3,6-diazabicyclo[3.1.1]heptan-3-yl]pyridin-3-yl]pyrazolo[1,5-a]pyridine-3-carbonitrile; LOXO-292
Appearance White to off-White powder
CAS # 2152628-33-4
Molecular Formula C₂₉H₃₁N₇O₃
Molecular Weight 525.6
Purity >98%
Solubility ~8 mg/ml in DMSO. Ultrasonication can be done to improve solubility.
InChi InChI=1S/C29H31N7O3/c1-29(2,37)18-39-24-9-25(28-21(10-30)13-33-36(28)17-24)20-5-6-26(31-12-20)34-15-22-8-23(16-34)35(22)14-19-4-7-27(38-3)32-11-19/h4-7,9,11-13,17,22-23,37H,8,14-16,18H2,1-3H3
PubChem CID 134436906
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.


Selpercatinib is a RET kinase inhibitor with IC₅₀ values ranging from 1 nM to 4 nM for wild type and mutant RET kinase. It has shown promising results in early phase clinical trials for RET-driven lung tumours with enhanced clinical activity and better tolerability.

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