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SDF-1alpha Antibody

based on 2 citations in multiple journalsSDF-1alpha Antibody24.1 4
Catalog #: 5387
SKU-Size Size Price Qty
5387-30T 30 µg
$89.00
5387-100 100 µg
$255.00
More Sizes Get Quote

Product Details

Antibody Target SDF-1a
Alternate Name SDF-1, SDF1, SDF 1, SDF-1a, SDF1a, SDF 1a, SDF-1alpha Polyclonal, Anti-SDF-1alpha antibody, SDF-1alpha antibody, Anti-SDF-1alpha, SDF-1alpha, Stromal cell-derived factor, pre-B-cell growth-stimulating factor, PBSF, CXC chemokine, CXCR4, LESTR, fusin
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen E. coli-expressed human SDF-1α
Accession # NP_001029058
Gene ID 6387
Appearance Colorless liquid
Concentration 0.5 mg/ml
Formulation 30 µg (0.5 mg/ml) affinity purified rabbit anti-human SDF-1α polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol and 0.01 thimerosal.
Purification Affinity purified
Species Reactivity Human, mouse, rat
Application Western blot
Application & Usage Western blot analysis (0.5-1 µg/ml). Based on researcher’s feedback, it can also be used in immunofluorescence and neutralization (2-10 µg/ml). However, the optimal conditions should be determined individually.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

SDF-1α (stromal cell-derived factor-α), also known as pre-B-cell growth-stimulating factor (PBSF), is a 70-amino acid CXC chemokine originally cloned from a bone marrow stromal cell line. Targeted deletion of SDF-1 gene resulted in defects of B-cell lymphopoiesis and bone marrow myelopoiesis. SDF-1 has been shown to be chemotactic for lymphocytes. In addition, SDF-1 was recently reported to be a ligand for CXCR4 (LESTR/fusin), a co-receptor for HIV-1 entry into T cells. SDF-1 binding to CXCR4 inhibits HIV-1 entry.


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Tomaso, E. et. al. Glioblastoma Recurrence after Cediranib Therapy in Patients: Lack of "Rebound" Revascularization as Mode of Escape. Cancer Res., Jan 2011; 71: 19 - 28.
Kondo K et al (2009) Arterioscler. Thromb. Vasc. Biol.; 29: 61 - 66.
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