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Product Details
| Cat # +Size | 1605-1 |
|---|---|
| Size | 1 mg |
| Alternate Name | N-Hydroxy-1,3-dioxo-1H-benz[de]isoquinoline-2(3H)-hexanamide |
| Appearance | White to off-white solid |
| CAS # | 287383-59-9 |
| Molecular Formula | C₁₈H₁₈N₂O₄ |
| Molecular Weight | 326.35 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (100 mM) |
| SMILES | C1=CC2=C3C(=C1)C(=O)N(C(=O)C3=CC=C2)CCCCCC(=O)NO |
| InChi | InChI=1S/C18H18N2O4/c21-15(19-24)10-2-1-3-11-20-17(22)13-8-4-6-12-7-5-9-14(16(12)13)18(20)23/h4-9,24H,1-3,10-11H2,(H,19,21) |
| InChi Key | JTDYUFSDZATMKU-UHFFFAOYSA-N |
| PubChem CID | 5186 |
| MDL Number | MFCD00386477 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
A relatively non-toxic Inhibitor of histone deacetylase (HDAC). Facilitates transcriptional activation (TGF-β/Smad4) in both stable and transient receptor assays in a concentration-dependent manner. At ~2 µg/ml (6-8 µM) concentrations, results in a greater than 100-fold increase in histone acetylation in PANC-1 cells.
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