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sCD30 Ligand, Human Recombinant

CD30L/CD30 interactions initiate a signaling cascade that lead to the activation of NF-Kappa B.
Catalog #: P1285

In stock

SKU-Size Size Price Qty
P1285-50 50 μg
$295.00
P1285-10 10 μg
$115.00
More Sizes Get Quote

Product Details

Alternate Name Soluble CD30 Ligand, TNFSF8, CD153, CD30L
Gene Symbol TNFRSF8
Accession # P28908
Source CHO cells
Appearance Lyophilized
Physical Form Description Lyophilized from 1x PBS.
Molecular Weight 21.3 kDa
Purity by SDS-PAGE ≥ 98%
Endotoxin Level <0.1 EU/μg
Biological Activity Determined by its ability to stimulate human IL-8 production by human PBMC using a concentration range of 10.0-25.0 ng/ml.
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Amino Acid Sequence HHHHHHHHP SPGGSGGQR TDSIPNSPD NVPLKGGNC SEDLLCILK RAPFKKSWA YLQVAKHLN KTKLSWNKD GILHGVRYQ DGNLVIQFP GLYFIICQL QFLVQCPNN SVDLKLELL INKHIKKQA LVTVCESGM QTKHVYQNL SQFLLDYLQ VNTTISVNV DTFQYIDTS TFPLENVLS IFLYSNSD
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

CD30 ligand (CD30L) is a type-II membrane-associated glycoprotein protein belonging to the TNF superfamily and is expressed primarily on certain B cells, T cells, and monocytes. CD30L binds specifically to CD30 (receptor), which is expressed on activated, but not resting, B and T cells, in lymphomas and various chronically inflamed tissues. CD30L/CD30 interactions initiate a signaling cascade that can ultimately lead to the activation of NF-Kappa B. CD30L/CD30 signaling exerts pleiotropic effects on normal cells, including cell death, differentiation, or cell division. Certain diseases, including Hodgkin’s lymphoma, allergic inflammation, diabetes (in NOD mice), and mycobacterial infection can also be affected by CD30L/CD30 signaling. The CD30L gene encodes for a 234 amino acid type II transmembrane protein, which contains a 37 amino acid cytoplasmic sequence, a 25 amino acid transmembrane domain and a 172 amino acid extracellular domain. Recombinant human soluble CD30L (sCD30L) is a 188 amino acid polypeptide corresponding to the extracellular domain, and contains an 8 residue N-terminal His -Tag.


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