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SCD1 Inhibitor

based on 2 citations in multiple journalsSCD1 Inhibitor24.1 4
A SCD1(stearoyl-CoA desaturase 1 inhibitor
Catalog #: 1716
SKU-Size Size Price Qty
1716-1 1 mg
1716-5 5 mg
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Product Details

Alternate Name 4-(2-Chlorophenoxy)-N-(3-(3-methylcarbamoyl)phenyl)piperidine-1-carboxamide; A-939572; A939572
Appearance Crystalline solid
CAS # 1032229-33-6
Molecular Formula C₂₀H₂₂ClN₃O₃
Molecular Weight 387.86
Purity ≥95% by HPLC
Solubility DMSO (~ 180 mg/ml)
InChi InChI=1S/C20H22ClN3O3/c1-22-19(25)14-5-4-6-15(13-14)23-20(26)24-11-9-16(10-12-24)27-18-8-3-2-7-17(18)21/h2-8,13,16H,9-12H2,1H3,(H,22,25)(H,23,26)
PubChem CID 24905400
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Cell-permeable. A potent and selective inhibitor of SCD1(stearoyl-CoA desaturase 1) (In vitro: IC₅₀ = 37 nM for hSCD1, <4 nM for mSCD1). Also exhibited in vivo efficacy with dose-dependent desaturation index lowering effect. SCD1 inhibition resulted in alterations in macrophage membrane lipid composition and marked hypersensitivity to toll-like receptor 4 agonists.

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Xiaodong Zhuang, The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication. Nat Commun., Jan. 2019; 30670689.
Iwasaki et al., Activating Transcription Factor 4 Links Metabolic Stress to Interleukin-6 Expression in Macrophages. Diabetes, Jan 2014; 63: 152 - 161.
Griffiths et al., Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth. Cancer & Metabolism 2013, 1:3
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