An allosteric Akt inhibitor
Catalog #: 1870 | abID:

Product Details

Alternate Name (2E, 6E)-2, 6-Bis(pyridine-4ylmethylene)cyclohexanone
Appearance Yellow crystalline solid
CAS # 871361-88-5
Molecular Formula C₁₈H₁₆N₂O
Molecular Weight 276.33
Purity ≥95% by HPLC
Solubility DMSO
InChi InChI=1S/C18H16N2O/c21-18-16(12-14-4-8-19-9-5-14)2-1-3-17(18)13-15-6-10-20-11-7-15/h4-13H,1-3H2/b16-12+,17-13+
PubChem CID 6018993
MDL Number MFCD05025493
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Cell-permeable. An allosteic Akt inhibitor that directly facilitates Akt ubiquitination in vitro and in vivo. SC66 displays a dual inhibitory activity that directly interferes with the pleckstrin homology (PH) domain binding to PIP₃ and facilitates Akt ubiquitination. Due to its dual inhibitory activity, SC66 displays a more effective growth suppression of transformed cells that contain a high level of Akt signaling, compared with other inhibitors of PIP₃/Akt pathway.

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