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SC-26196

A selective Δ6 desaturase inhibitor
Catalog #: B1580

In stock

SKU-Size Size Price Qty
B1580-5 5 mg
$135.00
B1580-25 25 mg
$535.00

Product Details

Alternate Name 2,2-diphenyl-5-[4-(pyridin-3-ylmethylideneamino)piperazin-1-yl]pentanenitrile
Appearance Beige solid
CAS # 218136-59-5
Molecular Formula C₂₇H₂₉N₅
Molecular Weight 423.55
Purity ≥98% by HPLC
Solubility DMSO (~10 mg/ml)
SMILES C1CN(CCN1CCCC(C#N)(C2=CC=CC=C2)C3=CC=CC=C3)N=CC4=CN=CC=C4
InChi C1CN(CCN1CCCC(C#N)(C2=CC=CC=C2)C3=CC=CC=C3)/N=C/C4=CN=CC=C4
InChi Key QFYKXKMYVYOUNJ-JBASAIQMSA-N
PubChem CID 9845201
MDL Number MFCD11226148
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

SC-26196 is a selective Δ6 desaturase inhibitor (IC₅₀ = 0.2 μM in vitro. It displays selectivity over Δ5 and Δ9 desaturases (IC₅₀ values are >200 μM in vitro). Exhibits anti-inflammatory properties in a mouse edema model. Eliminates CSCs from ovarian cancer cell lines and inhibits sphere formation in vitro. SC-26196 is orally active in vivo, decreasing edema in the carrageenan paw edema model in mice.


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