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SBI-0206965

An autophagy kinase ULK1 inhibitor
Catalog #: 9580
SKU-Size Size Price Qty
9580-5 5 mg
$125.00
9580-25 25 mg
$495.00
More Sizes Get Quote

Product Details

Alternate Name 2-((5-bromo-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)oxy)-N-methylbenzamide
Appearance Off-white solid
Molecular Formula C₂₁H₂₁BrN₄O₅
Molecular Weight 489.33
Purity ≥98% by HPLC
Solubility DMSO >20 mg/ml)
SMILES O=C(NC)C1=CC=CC=C1OC2=NC(NC3=CC(OC)=C(OC)C(OC)=C3)=NC=C2Br
InChi InChI=1S/C21H21BrN4O5/c1-23-19(27)13-7-5-6-8-15(13)31-20-14(22)11-24-21(26-20)25-12-9-16(28-2)18(30-4)17(10-12)29-3/h5-11H,1-4H3,(H,23,27)(H,24,25,26)
InChi Key NEXGBSJERNQRSV-UHFFFAOYSA-N
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

SBI-0206965 is a potent, selective and cell permeable autophagy kinase ULK1 inhibitor. It inhibits ULK1 kinase with IC₅₀ of 108 nM and the highly related kinase ULK2 with IC₅₀ of 711 nM. SBI-0206965 suppresses ULK1-mediated phosphorylation events in cells, regulating autophagy and cell survival. SBI-0206965 greatly synergizes with mechanistic target of rapamycin (mTOR) inhibitors to kill tumor cells.


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