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SBE13 hydrochloride

A potent and selective PLK1 (Polo-like kinase 1) inhibitor
Catalog #: 2847
SKU-Size Size Price Qty
2847-10 10 mg
$125.00
2847-50 50 mg
$495.00
More Sizes Get Quote

Product Details

Alternate Name N-[[4-[(6-Chloro-3-pyridinyl)methoxy]-3-methoxyphenyl]methyl]-3,4-dimethoxybenzeneethanamine hydrochloride
Appearance White solid
CAS # 1052532-15-6
Molecular Formula C₂₄H₂₇ClN₂O₄.HCl
Molecular Weight 479.4
Purity ≥98% by HPLC
Solubility DMSO (>40 mg/ml) or H2O (~4 mg/ml with slight warming)
SMILES COC1=C(C=C(C=C1)CCNCC2=CC(=C(C=C2)OCC3=CN=C(C=C3)Cl)OC)OC.Cl
InChi InChI=1S/C24H27ClN2O4.ClH/c1-28-20-7-4-17(12-22(20)29-2)10-11-26-14-18-5-8-21(23(13-18)30-3)31-16-19-6-9-24(25)27-15-19;/h4-9,12-13,15,26H,10-11,14,16H2,1-3H3;1H
InChi Key QBGSVDJLQQXEGG-UHFFFAOYSA-N
PubChem CID 11948807
MDL Number MFCD20036266
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

SBE13 HCl is a potent and selective PLK1 (Polo-like kinase 1) inhibitor (IC₅₀ = 200 pM). Displays activity against PLK2 and PLK3 at higher concentrations (IC₅₀ values of 66 µM and 875 nM, respectively). Has no effect on Aurora kinase A.


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