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Product Details
| Alternate Name | 11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene |
|---|---|
| Appearance | Crystalline solid |
| CAS # | 937272-79-2 |
| Molecular Formula | C₂₈H₃₂N₄O₃ |
| Molecular Weight | 472.58 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO |
| SMILES | C1CCN(C1)CCOC2=C3COCC=CCOCC4=CC=CC(=C4)C5=NC(=NC=C5)NC(=C3)C=C2 |
| InChi | InChI=1S/C28H32N4O3/c1-2-13-32(12-1)14-17-35-27-9-8-25-19-24(27)21-34-16-4-3-15-33-20-22-6-5-7-23(18-22)26-10-11-29-28(30-25)31-26/h3-11,18-19H,1-2,12-17,20-21H2,(H,29,30,31)/b4-3+ |
| InChi Key | HWXVIOGONBBTBY-ONEGZZNKSA-N |
| PubChem CID | 46216796 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
A potent JAK2/FLT3 inhibitor. Displays equipotent activity against JAK2 (I₅₀ = 23 nM) and FLT3 (IC₅₀ = 22 nM). SB1518 displays potent anti-proliferative effects on myeloid and lymphoid cell lines driven by mutant or wild-type JAK2 or FLT3, resulting from cell cycle arrest and induction of apoptosis.
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