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SB1518 (Pacritinib)

A potent JAK2/FLT3 inhibitor
Catalog #: 2450
SKU-Size Size Price Qty
2450-1 1 mg
$115.00
2450-5 5 mg
$455.00
More Sizes Get Quote

Product Details

Alternate Name 11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene
Appearance Crystalline solid
CAS # 937272-79-2
Molecular Formula C₂₈H₃₂N₄O₃
Molecular Weight 472.58
Purity ≥98% by HPLC
Solubility DMSO
SMILES C1CCN(C1)CCOC2=C3COCC=CCOCC4=CC=CC(=C4)C5=NC(=NC=C5)NC(=C3)C=C2
InChi InChI=1S/C28H32N4O3/c1-2-13-32(12-1)14-17-35-27-9-8-25-19-24(27)21-34-16-4-3-15-33-20-22-6-5-7-23(18-22)26-10-11-29-28(30-25)31-26/h3-11,18-19H,1-2,12-17,20-21H2,(H,29,30,31)/b4-3+
InChi Key HWXVIOGONBBTBY-ONEGZZNKSA-N
PubChem CID 46216796
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A potent JAK2/FLT3 inhibitor. Displays equipotent activity against JAK2 (I₅₀ = 23 nM) and FLT3 (IC₅₀ = 22 nM). SB1518 displays potent anti-proliferative effects on myeloid and lymphoid cell lines driven by mutant or wild-type JAK2 or FLT3, resulting from cell cycle arrest and induction of apoptosis.


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