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SB1317 (TG-02)

A potent inhibitor of CDK2, JAK2, and FLT3
Catalog #: B3218
SKU-Size Size Price Qty
B3218-5 5 mg
$115.00
B3218-25 25 mg
$455.00
More Sizes Get Quote

Product Details

Alternate Name (16E)-14-methyl-20-oxa-5,7,14,27-tetrazatetracyclo[19.3.1.12,6.18,12]heptacosa-1(25),2(27),3,5,8,10,12(26),16,21,23-decaene; Zotiraciclib
Peptide Sequence N/A
Appearance Crystalline solid
CAS # 1204918-72-8
Molecular Formula C₂₃H₂₄N₄O
Molecular Weight 372.46
Purity ≥98%
Solubility >20 mg/ml DMSO
SMILES CN1CC=CCCOC2=CC=CC(=C2)C3=NC(=NC=C3)NC4=CC=CC(=C4)C1
InChi InChI=1S/C23H24N4O/c1-27-13-3-2-4-14-28-21-10-6-8-19(16-21)22-11-12-24-23(26-22)25-20-9-5-7-18(15-20)17-27/h2-3,5-12,15-16H,4,13-14,17H2,1H3,(H,24,25,26)/b3-2+
InChi Key VXBAJLGYBMTJCY-NSCUHMNNSA-N
PubChem CID 16739650
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

SB1317 is a potent inhibitor of CDK2, JAK2, and FLT3 with IC50 of 13, 73, and 56 nM, respectively. SB1317 may be useful for the treatment of cancer that crosses the blood brain barrier and acts by depleting Myc through the inhibition of cyclin-dependent kinase 9 (CDK9).


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