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A potent, selective and ATP-competitive, glycogen synthase kinase-3 (GSK-3) inhibitor
Catalog #: B1954
SKU-Size Size Price Qty
B1954-5 5 mg
B1954-25 25 mg
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Product Details

Alternate Name 3-[(3-chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione
Appearance Yellow solid
CAS # 264218-23-7
Molecular Formula C₁₆H₁₀ClN₃O₅
Molecular Weight 359.73
Purity ≥98% by HPLC
Solubility DMSO (>15 mg/ml)
SMILES C1=CC=C(C(=C1)C2=C(C(=O)NC2=O)NC3=CC(=C(C=C3)O)Cl)[N+](=O)[O-]
InChi InChI=1S/C16H10ClN3O5/c17-10-7-8(5-6-12(10)21)18-14-13(15(22)19-16(14)23)9-3-1-2-4-11(9)20(24)25/h1-7,21H,(H2,18,19,22,23)
PubChem CID 4210951
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


SB-415286 is a potent, selective and ATP-competitive glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 31 nM for GSK-3α). Displays minimal activity against 24 other protein kinases (IC₅₀ > 10 μ M). Stimulates glycogen synthesis, gene transcription and is neuroprotective.

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