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SB-590885

A potent B-Raf inhibitor
Catalog #: B1708
SKU-Size Size Price Qty
B1708-5 5 mg
$115.00
B1708-25 25 mg
$455.00
More Sizes Get Quote

Product Details

Alternate Name SB-590885; SB590885; SB 590885; (E)-5-(2-(4-(2-(dimethylamino)ethoxy)phenyl)-5-(pyridin-4-yl)-1H-imidazol-4-yl)-2,3-dihydro-1H-inden-1-one oxime; N,N-dimethyl-2-[4-[(4Z)-4-(1-nitroso-2,3-dihydroinden-5-ylidene)-5-(1H-pyridin-4-ylidene)-1H-imidazol-2-yl]phenoxy]ethanamine
Appearance Solid
CAS # 405554-55-4
Molecular Formula C₂₇H₂₇N₅O₂
Molecular Weight 453.54
Purity >98%
Solubility DMSO
SMILES CN(C)CCOC1=CC=C(C=C1)C2=NC(=C3C=CC4=C(CCC4=C3)N=O)C(=C5C=CNC=C5)N2
InChi InChI=1S/C27H27N5O2/c1-32(2)15-16-34-22-7-3-19(4-8-22)27-29-25(18-11-13-28-14-12-18)26(30-27)21-5-9-23-20(17-21)6-10-24(23)31-33/h3-5,7-9,11-14,17,28H,6,10,15-16H2,1-2H3,(H,29,30)/b26-21+
InChi Key DPCXEUSDRQOOGZ-YYADALCUSA-N
PubChem CID 11465183
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

SB590885 is a potent B-Raf inhibitor with Ki of 0.16 nM, 11-fold greater selectivity for B-Raf over c-Raf, no inhibition to other human kinases.


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