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SB-743921 Hydrochloride

A potent kinesin spindle protein (KSP) inhibitor
Catalog #: B3215
SKU-Size Size Price Qty
B3215-5 5 mg
B3215-25 25 mg
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Product Details

Alternate Name N-(3-Aminopropyl)-N-[(1R)-1-[7-chloro-4-oxo-3-(phenylmethyl)-4H-1-benzopyran-2-yl]-2-methylpropyl]-4-methylbenzamide hydrochloride
Peptide Sequence N/A
Appearance Off-white solid
CAS # 940929-33-9
Molecular Formula C₃₁H₃₃ClN₂O₃.HCl
Molecular Weight 553.52
Purity ≥98% by HPLC
Solubility >40 mg/ml DMSO
SMILES CC(C)[[email protected]@H](N(CCCN)C(C1=CC=C(C)C=C1)=O)C2=C(CC3=CC=CC=C3)C(C4=C(O2)C=C(Cl)C=C4)=O.Cl
InChi 1S/C31H33ClN2O3.ClH/c1-20(2)28(34(17-7-16-33)31(36)23-12-10-21(3)11-13-23)30-26(18-22-8-5-4-6-9-22)29(35)25-15-14-24(32)19-27(25)37-30;/h4-6,8-15,19-20,28H,7,16-18,33H2,1-3H3;1H/t28-;/m1./s1
PubChem CID 49867937
MDL Number MFCD18385010
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


SB-743921 hydrochloride is potent kinesin spindle protein (KSP) inhibitor (Ki = 0.1 nM). Displays almost no affinity to MKLP1, Kin2, Kif1A, Kif15, KHC, Kif4, and CENP-E. Induces cell mitotic arrest and apoptosis in vitro. Inhibits the growth of a range of tumor cells in vitro, including colon (HCT 116), prostate (PC-3) and leukemia (K-562) cancer cell lines.

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