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SB-431542

TGF-β1 receptor (ALK5) inhibitor
Catalog #: 1674
SKU-Size Size Price Qty
1674-5 5 mg
$365.00
1674-1 1 mg
$110.00
More Sizes Get Quote

Product Details

Alternate Name 4-[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide
Appearance Crystalline solid
CAS # 301836-41-9
Molecular Formula C₂₂H₁₈N₄O₃
Molecular Weight 384.39
Purity ≥98% by HPLC
Solubility DMSO (20 mg/ml) or EtOH (2 mg/ml)
SMILES C1OC2=C(O1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5
InChi InChI=1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26)
InChi Key FHYUGAJXYORMHI-UHFFFAOYSA-N
PubChem CID 4521392
MDL Number MFCD11045982
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A potent and selective inhibitor of the TGF-β1 receptor ALK5 (IC₅₀ = 94 nM). It inhibits ALK4 only at higher concentrations (IC₅₀ = 140 nM). Suppresses renewal in embryonic and induced pluripotent stem (iPS) cells and promotes their differentiation through its effect on Smad signaling pathway.


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Fengsong Liu, et al., ( 2018) Bone morphogenetic protein and activin membrane-bound inhibitor suppress bone cancer progression in MG63 and SAOS cells via regulation of the TGF-β-induced EMT signaling pathway, Oncology Letters, Oct. 2018, 30250579
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